The Metals in Medicine It's description cisplatin and other platinum anticancer drugsruthenium, titanium, and gallium for treating cancergold compounds for treating arthritis, cancer, and other diseasesvanadium, copper, and zinc in medicinemetal complexes for diagnosing diseasethe emerging field of metals in nanomedicine.Metals in Medicine distils the essence of this important topic for undergraduate and graduate students in chemistry, biochemistry, biology and the related areas of biophysics, pharmacology and bioengineering. Working from basic chemical principles,Metals in Medicine presents a complete and methodical approach to the topic. Introductory chapters discuss important bonding concepts applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. In recent years the field of medicinal inorganic chemistry has extended far beyond the traditional areas of platinum anticancer drugs. As metal-based drugs become increasingly common in the drug market, an understanding of medicinal inorganic chemistry is essential for successful drug design and development.Throughout the book, Feature Boxes expand on related topics such as drug discovery, synthesis and principles behind medical techniques. Following each chapter there are specifically designed exercises, with solutions, that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in the topic being addressed.Following this introduction, chapters focus on individual metallo-drugs and agents for treating and detecting disease, examining their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply.
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